Kerato-conjunctivitis Sicca and Collagen Diseases
نویسنده
چکیده
KERATO-CONJUNCTIVITIS sicca is more often seen by and is of more interest to the ophthalmologist than the physician. It is little known and yet not uncommon. The usual syndrome is one affecting mainly middle-aged women and consisting of kerato-conjunctivitis sicca, rhinitis sicca, xerostoma, pharyngitis sicca, and parotid enlargement, and frequently including a chronic polyarthritis (Sjogren's syndrome). The aetiology is obscure, and from time to time such conditions as endocrine glandular dysfunction, focal sepsis, bacterial infection, virus infection, allergy, and vitamin deficiency have been put forward as possible factors. Association of this type of conjunctivitis has been noticed to occur in conditions which are recognized to be themselves of the same family. The investigations carried out in all cases included haemoglobin estimation, blood count and differential white blood cell count, erythrocyte sedimentation rate, and Wassermann reaction, and Kahn test. X rays were taken of the chest, parotid glands, and joints, when the latter were affected. Blood urea, serum protein, and liver function tests were carried out. In the last four cases, because of the related generalized disease, there were extensive investigations. These varied slightly from case to case, but included, in addition to the above: sternal marrow biopsy, blood and urine cultures, serum agglutins for B. abortus, etc., blood pyruvic acid, serum electrolytes, serum phosphorus and calcium, renal function tests, creatine excretion, urinary coproporphyrins, and electrocardiography.
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